Congenital Hypothyroidism: Space–Time Clustering of Thyroid Dysgenesis Indicates a Role for Environmental Factors in Disease Etiology

Congenital and Juvenile Hypothyroidism Due to Thyroid Dysgenesis.

Following the initial description of an ectopic thyroid by Verneuil, ( 1 ) it remained only as an anatomical curiosity for many years. Hunt ( 2 ) described dysphagia and obstruction of the upper larynx caused by a lingual thyroid and suggested the clinical importance of this entity. Mont gomery ( 3 ) has reviewed most of the reported cases, and observed that surgi cal ablation of the ectopic ti...

Familial congenital hypothyroidism due to thyroid dysgenesis: A case report of largest family

Introduction: Congenial hypothyroidism due to thyroid dysgenesis is usually regarded as sporadic. However, a small but significant proportion of familial cases have been identified (2%). Herein, we describe a case report of unusually large family of 10 siblings, out of which five were affected with congenital hypothyroidism, which is supposed to be the world’s largest series of familial congeni...

Developmental Outcomes in Early-treated Congenital Hypothyroidism: Specific Concern in Tc99m Thyroid Scan Role

Background Congenital hypothyroidism (CH) may cause alterations in the child's global development. The current study aimed to screen the global development of children with and without congenital hypothyroidism, focusing on communication, and cognitive abilities and to ...

Investigation of the Risk Factors for Congenital Hypothyroidism in Iran: A Population-Based Case-Control Study

Background Congenital hypothyroidism (CH) is one of the most common causes of mental disability, which can be prevented in the case of early diagnosis and treatment. We aimed to study the some relevant risk factors for CH in neonates born in Khorasan Razavi Province, Iran. Materials and Methods: This was a population-based case-control study conducted on 97,380 neonates.The study population c...

Congenital Hypothyroidism due to Thyroid Dysgenesis: From Epidemiology to Molecular Mechanisms